African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Identify potential chronic heart failure related transcription factors by network analysis

Wu Gang1*, Xie Qiang2#, Cheng Mian3, Jiang Xuejun1, Yang Bo1 and Huang He1
  1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China. 2Department of Cardiovascular disease, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China. 3Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Email: [email protected]

  •  Accepted: 23 June 2011
  •  Published: 23 October 2011



Chronic heart failure (CHF) is characterized by diminished cardiac output and pooling of blood in the venous system. Using transcriptome data, we constructed a regulation network to identify the potential genes that related to heart failure. In the network, some of transcription factors and its’ target genes have been proved to be related to heart failure in previous study. According to the regulation network, we found some new transcription factors and target genes, which have not been proved to be directly related with; we also found MYC, TP53 and ETS2 regulate each other. Our work demonstrated that regulationof network analysis is useful in identification of the candidate genes in heart failure.


Key words: Chronic heart failure, transcription factors, regulation network.