Abstract

It is becoming highly challenging for scientific community around the world to battle against rapidly increasing deadly superbugs. Because of heavy exposure of antibiotics and inadequate regimen against infectious organisms, antibiotic resistance in these pathogens has created an immense problem worldwide. Combined antibiotic therapy is frequently recommended for the treatment of such problems. This study is focused to establish in vitro antibiotic synergy profiles of combinations of β-lactams and aminoglycoside against drug resistant clinical isolates of Pseudomonas aeruginosa.Synergy was determined by checkerboard double dilution method. It was recorded that the combination of cephalexin and amoxicillin was most significantly synergistic (P<0.0001) followed by streptomycin and ampicillin (P=0.0011), hence these two possible treatment options clearly point to the significance of antibiotic synergy.

Key word: Antibiotic, synergism, multidrug resistant P. aeruginosa (MDRPA).