African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5230

Antimicrobial activities of the whole plant of Cestrum nocturnum against pathogenic microorganisms

Murad Ali Khan 1 *, Humaira Inayat 2,3 , Haroon Khan 4,5 , Mohammmad Saeed 4 , Ikhtair Khan 3    and Inayat-Ur-Rahman 2 
  1Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan.  2Pakistan Council of Scientific and Industrial Research Laboratories Complex, Jamrud Road, Peshawar, Pakistan.  3Department of Chemistry University of Peshawar, Peshawar 25120, Pakistan.  4Department of Pharmacy University of Peshawar, Peshawar 25120, Pakistan.  5Gandhara College o f Pharmacy, Gandhara University, Peshawar, Pakistan.
Email: : [email protected]

  •  Accepted: 01 March 2011
  •  Published: 18 March 2011

Abstract

 

The crude methanol extract of the whole plant of Cestrum nocturnum L. (Solanaceae) and its 
subsequent fractions were tested against various bacterial and fungal strains. With the exception of 
Salmonella typhi, the tested samples showed marked antibacterial activity against Pseudomonas 
aeruginosa, Staphylococcus aurous, Bacillus subtilis, Escherichia coli and Shigella flexenari. The 
minimum inhibitory concentrations (MICs) ranged from 19 to 280 µg/ml. The crude extract and fractions 
were also susceptible to Candida species and Microsporium canis. The minimum inhibitory 
concentrations (MICs) for various fungi ranged from 170 to 290 µg/ml. In phytochemical analysis, the 
crude form and fractions of plant showed the presence of various phytochemical chemical groups like 
glycosides, alkaloids, saponins, phenols, flavonoids, sterols and tannins. Therefore, the current 
findings can be attributed to these groups.   
 
Key words:  Cestrum nocturnum L., antibacterial, antifungal, phytochemicals.