Abstract

Here we aim at comparing the accuracy of Padtan Teb disc (Iranian DDA) with epsilometer test (E-test) for antibiotic susceptibility, in Escherichia coli isolated from patients with urinary tract infections (UTI) in Shariati University Hospital. Two hundred and fifty patients with UTIs, diagnosed with urinary culture which was confirmed to be infected with E. coli were recruited.  The highest sensitivity was perceived for Nitrofurantoin (91.5% in E test and 61.3% in Iranian DDA). The lowest sensitivity in two methods was detected for TMP-SMX (37.9% in Iranian DDA, and 34.4 in E test). The highest resistance was for Trimetoprim sulfametoxazole (Iranian DDA 53.2%, 61.6% in E test), while the lowest resistance in two methods were obtained for Nitrofurantoin (14.5% Iranian DDA and 3.5% in E test). We hence concluded that the differences between Iranian DDA and Swedish E test results are prominent, and the sensitivity of Iranian DDA is not enough to determine antibiotic sensitivity therefore the results of this method should be confirm by other reliable ones such as Swedish E test.

Key words: Epsilometer test, agar disc diffusion, urinary tract infections (UTI),Escherichia coli, antibiogram