African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Antinociceptive and healing activity of the methanolic and hydroethanolic extracts of Caulerpa taxifolia

Evandro Valentim da Silva
  • Evandro Valentim da Silva
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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Gabriela Cavalcanti da Silva
  • Gabriela Cavalcanti da Silva
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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Carla Andrea de Moura
  • Carla Andrea de Moura
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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Jefferson de Lima
  • Jefferson de Lima
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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Marcia Raquel Cedrin Vieira
  • Marcia Raquel Cedrin Vieira
  • Northern College of Parana, Brazil
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Laureana de Andrade Lima
  • Laureana de Andrade Lima
  • Northern College of Parana, Brazil
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Danielle Maria Bastos de Souza
  • Danielle Maria Bastos de Souza
  • University Federal Rural of Pernambuco, Brazil.
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José Ferreira Silva Neto
  • José Ferreira Silva Neto
  • University Federal Rural of Pernambuco, Brazil.
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George Chaves Jimenez
  • George Chaves Jimenez
  • University Federal Rural of Pernambuco, Brazil.
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Fálba Bernadete Ramos dos Anjos
  • Fálba Bernadete Ramos dos Anjos
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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Ivone Antonia de Souza
  • Ivone Antonia de Souza
  • Antibiotics Department, Federal University of Pernambuco, Universitaria City, Recife, PE, Brazil.
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  •  Received: 15 January 2016
  •  Accepted: 28 June 2016
  •  Published: 22 July 2016

Abstract

This study aimed to evaluate the healing and analgesic action of methanolic extract and hydroalcoholic of C. taxifolia, and check the percentage of soluble proteins available in the extract of this vegetable. The collection of C. taxifolia occurred on the beach of Barra do Sirinhaém - PE, processed for testing. The animals used in the test were Swiss mice, and Mus musculus of species. For healing activity and histopathological analysis, albino rats Rattus norvegicus species, linnhagem Wistar were used. The protein content of the crude extract of C. Taxifolia has not yet been determined. The data revealed that the average displaying writhing in animal control group was 13.86. The standard group was 7.83; the group treated with hydroethanolic extract of C. taxifolia at a dose of 50 mg/kg was 8.83 and those treated with 100 mg/kg was 6.5. In the groups treated with the methanol extract of 100 mg/kg, the average value of writhing was 7.67, while 50 mg/kg resulted in 9.26 average value. It was shown that hydroethanolic and methanol extract led to early healing ofwound with epithelialized keratinized tissue and re-epithelialization; involving the restructuring of the skin appendages, during treatment and in the absence of crust.

 

Key words: Healing, seaweed, protein, repair.