African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Promising antioxidant and cytotoxic activities of the aqueous ethanolic extract of carob leaves

Khaled Nagib1, Omayma A. Eldahshan2* and Walid F. A. M. El-Khatib3
1Department of Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 2Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University,Cairo, Egypt. 3Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Email: [email protected]

  •  Accepted: 10 June 2010
  •  Published: 30 June 2010

Abstract

Plants are endless reservoir for several phytochemicals including antioxidant and cytotoxic drugs. The objective of this study was the investigation of the antioxidant and the cytotoxic activities (against Vero and HEp-2 cell lines) of the aqueous ethanolic extract of carob leaves. The extract inhibited xanthine oxidase at IC50 of 244 μg/ml. There is a marked cytotoxic activity of crude aqueous extract of carob on both mammalian cell lines (Vero and HEp-2) and the effect is more obvious on the human cell line (HEp-2). The results revealed that the crude aqueous extract of carob leaves could be a promising source for antioxidant as well as antitumor bioactive agents.
 

Key words: Carob leaves, aqueous ethanolic extract, Ceratonia siliqua, antioxidant, xanthine oxidase, cytotoxicy.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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