African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Obesity related alterations in kidney function and plasma cytokines: Impact of sibutramine and diet in male Wistar rats

Francis Uchenna AGU
  • Francis Uchenna AGU
  • Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine University of Nigeria Enugu Campus, Enugu State, Nigeria.
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Melford Uche ELENDU
  • Melford Uche ELENDU
  • Department of Physiology, Imo State University Owerri, Nigeria.
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Hope Kelechi OKECHUKWU
  • Hope Kelechi OKECHUKWU
  • Department of Anatomy, Abia State University, Uturu, Abia State, Nigeria.
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Chikodili Adolphus MBAH
  • Chikodili Adolphus MBAH
  • Department of Anatomy, Abia State University, Uturu, Abia State, Nigeria.
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Kennedy Chinonye OBIOHA
  • Kennedy Chinonye OBIOHA
  • Department of Paediatrics, Federal Medical Centre, Owerri, Imo State, Nigeria.
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Isaiah Orji ABALI
  • Isaiah Orji ABALI
  • Department of Surgery, College of Medicine, Abia State University, Uturu, Nigeria.
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Eghosa Edorisiagbon IYARE
  • Eghosa Edorisiagbon IYARE
  • Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine University of Nigeria Enugu Campus, Enugu State, Nigeria.
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and Daniel Chukwu NWACHUKWU
  • and Daniel Chukwu NWACHUKWU
  • Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine University of Nigeria Enugu Campus, Enugu State, Nigeria.
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  •  Received: 22 March 2022
  •  Accepted: 19 October 2022
  •  Published: 30 November 2022

References

Adeloye D, Ige-Elegbede JO, Ezejimofor M, Owolabi EO, Ezeigwe N, Omoyele C, Mpazanje RG, Dewan MT, Agogo E, Gadanya MA, Alemu W, Harhay MO, Auta A and Adebiyi AO (2021). Estimating the prevalence of overweight and obesity in Nigeria in 2020: a systematic review and meta-analysis. Annal of Medicine 53(1):495-507.
Crossref

 

Ajiboye TO, Akinpelu SA, Muritala HF (2014). Trichosanthes cucumerina fruit extenuates dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high-fat diet-fed rats. Journal of Food Biochemistry 38(5):480-490.
Crossref

 

Borges CS, Missassi G, Pacini ESA, Kiguti LRA, Sanabria M, Silva RF (2013). Slimer or fertile? Pharmacological mechanisms involved in Reduced Sperm Quality and Fertility in Rats Exposed to Anorexigen Sibutramine. PLoS ONE 8(6):66091.
Crossref

 

Cao H (2014). Adipocytokines in obesity and metabolic disease. Journal of Endocrinology 220:2.
Crossref

 

Diane A (2008). Interleukin-6, TNF-alpha and interleukin-1 beta levels in blood and tissue in severely burned rats. European Cytokine Network 19:1-7.

 

Di Renzo L, Gualtieri P, Pivari F (2020). Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey. Journal of Translational Medicine 18:229.
Crossref

 

Dimitrov IV, Kamenov VI, Boyadjiev NP, Georgieva KN, Bivolarska AV, Draganova-Filipova MN, Angelova-Hristova PA, Delchev S, Daskalova E, Gerginska F, Stankova TR, Gramatikov V (2019). Impact of a high-fat diet on the development of chronic inflammation in heart of Wistar rats. Folia Medica (Plovdiv) 61(3):404-410
Crossref

 

Dittmann K, Hannemann A, Wallaschofski H (2013). U-shaped association between central body fat and the urinary albumin-to- creatinine ratio and microalbuminuria. BMC Nephrology 14:87.
Crossref

 

Farouk H, Mahmould SS, El-Sayeh BA, Sharaf OA (2015). Effect of grapefruit juice and sibutramine on body weight in obese rats. African Journal of Pharmacy and Pharmacology 9(8):265-273.
Crossref

 

Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA (2011). Inflammation, oxidative stress, and obesity. International Journal Molecular Science 12(5):3117-3132.
Crossref

 

Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH (2001). Impact of over weight on the risk of developing common chronic diseases during a 10-year period. Archive of Internal Medicine 161:1581-1586
Crossref

 

Finucane MM, Stevens, GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN (2011). National, regional, and global trends inbody-mass since 1980, systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377:557-567.
Crossref

 

Flak JN, Myers MG Jr (2016). Minireview: CNS Mechanisms of Leptin Action. Molecular Endocrinology 30(1):3-12.
Crossref

 

Forman JP, Fisher NDL, Schopick EL, Curhan GC (2008). Higher Levels of Albuminuria within the Normal Range Predict Incident Hypertension. Journal of American Society of Nephrology 19:10.
Crossref

 

Ghantous CM, Azrak Z, Hanache S, Abou-Kheir W, Zeidan A (2015). Differential Role of Leptin and Adiponectin in Cardiovascular System. International Journal of Endocrinology 2015:534320.
Crossref

 

Hall JE, Brands MW, Henegar JR (1999). Mechanisms of hypertension and kidney disease in obesity. Annals of New York Academy of Sciences 18(892):91-107.
Crossref

 

Hariri N, Thibault L (2010). High-fat diet-induced obesity in animal models. Nutrition Respiratory Review 23:270-299.
Crossref

 

Hioki C, Yoshida T, Kogure A, Yoshimoto K, Shimatsu A (2010). Growth Hormone Administration Controls Body Composition Associated with Changes of Thermogenesis in Obese KK-Ay Mice. The Open Endocrinology Journal 4:3-8.
Crossref

 

Hoffman JF, Fan AX, Neuendorf EH, Vergara VB, Kalinich JF (2018). Hydrophobic Sand Versus Metabolic Cages: A Comparison of Urine Collection Methods for Rats (Rattus norvegicus). Journal of American Association Laboratory Animal Science 57(1):51-57.

 

Imig JD, Ryan MJ (2013). Immune and inflammatory role in renal disease. Comprehensive Physiology 3:957-976.
Crossref

 

Kern L, Mittenbühler MJ, Vesting AJ, Ostermann AL, Wunderlich CM, Wunderlich FT (2018). Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers (Basel) 11(1):24.
Crossref

 

Kovesdy CP, Susan LF, Zoccali C (2016). Obesity and Kidney Diseases:Hidden Consequences of the Epidmic. Canadian Journal of Kidney Health and Disease 4:1-10.
Crossref

 

Kramer H, Tuttle KR, Leehey D, Luke A, Durazo-Arvizu R, Shoham D, Cooper R, Beddhu S (2009). Obesity management in adults with CKD. American Journal of Kidney Disease. 53(1):151-165.
Crossref

 

Lazzara MJ, Deen WM (2007). Model of albumin re-absorption in the proximal tubule. American Journal Physiology - Renal Physiology 292:430-439.
Crossref

 

Lee MO (1929). Determination of the surface area of the white rat with its application to the expression of metabolic results. American Journal of Physiology 89:24-33.
Crossref

 

Lin J, Hu FB, Curhan GC (2010). Associations of Diet with Albuminuria and Kidney Function Decline. Clinical Journal of American Society of Neprology 5(5):836-843.
Crossref

 

Minoo F, Mahdavi-Mazde M, Abbasi MR (2015). Impact of the severity of obesity on microalbuminuria in obese normotensive non-diabetic individuals. Journal of Renal Injury Prevention 4:34-38.

 

Naber T, Purohit S (2021). Chronic Kidney Disease: Role of Diet for a Reduction In the severity of the Disease. Nutrients.
Crossref

 

National Kidney Foundation (2002). K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. American Journal of Kidney Disease 39:S1-S266.

 

Nwachukwu DC, Agu FU, Nwachukwu ZN (2016). Pattern of renal impairment among hypertensive subjects in Umuahia, South East Nigeria. International journal of Medicine and Medical Sciences 8(5):45-50.
Crossref

 

Seo WJ, Lee GM, Hwang JH (2016). Association between body mass index, waist circumference and prevalence of microalbuminuria in Korean adults of age 30 years and older without diabetes, hypertension, renal failure, or overt proteinuria: the 2013 Korean National health and nutrition examination survey. Korean Journal of Family Medicine 37:57-63.
Crossref

 

Stevens PE, Levin A (2013). Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: improving global outcomes 2012 clinical practice guideline. Annals of Internal Medicine 158(11):825-830.
Crossref

 

Tamba S, Nakatsuji H, Kishida K (2010). Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men. Atherosclerosis 211:601-605.
Crossref

 

Toora BD, Rajagopal G (2002). Measurement of creatinine by Jaffe.s reaction-determination of concentration of sodium hydroxide required for maximum colour development in standard, urine and protein free filtrate of serum. India Journal Experimental Biology 40(3):352-354.

 

Tsujimoto T, Sairenchi T, Iso H (2014). The dose-response relationship between body mass index and the risk of incident stage ≥3 chronic kidney disease in a general Japanese population: the Ibaraki prefectural health study (IPHS). Journal of Epidemiology 24:444-451.
Crossref

 

Wang CY, Liao JK (2012). A mouse model of diet-induced obesity and insulin resistance. Methods Molecular Biology 821:421-433.
Crossref

 

Wang S, Reed DB, Goli S (2011). Blood leptin and C-reactive protein provide more sensitive assessment than blood lipids and other inflammatory biomarkers in overweight university students. Nutrition Research 31:586-593.
Crossref

 

World Health Organization (2020). Obesity and overweight. 

 

Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C, Beguinot F (2019). Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Frontiers in Physiology 10:103389.
Crossref