African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Clinical and microbiological effects of systemic ciprofloxacin and metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis

Nasrin Esfahanizadeh
  • Nasrin Esfahanizadeh
  • Department of Periodontology, School of Dentistry, Islamic Azad University, Iran
  • Google Scholar
Soroosh Khalilinejad*
  • Soroosh Khalilinejad*
  • Department of Periodontology, School of Dentistry, Islamic Azad University, Iran
  • Google Scholar
Leyla Zonubi
  • Leyla Zonubi
  • Department of Microbiology, School of Medical Sciences, Iran University of Medical Sciences, Iran
  • Google Scholar


  •  Received: 10 September 2010
  •  Accepted: 07 April 2014
  •  Published: 29 April 2014

References

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Bain CA, Beagrie GS, Bourgoin J, Delorme F, Holthuis A, Landry RG, Roy S, Schuller P, Singer D, Turnbull R (1994). The effects of spiramycin and/or scaling on advanced periodontitis in humans. J. Can. Dent. Assoc. 60:209-217.
PubMed
 
Flemmig TF, Milian E, Karch H, Klaiber B (1998). Differential clinical treatment outcome after systemic Metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Prophyromonas gingivalis. J. Clin. Periodontol. 25:380-387.
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Heller D, Varela VM, Silva-Senem MX, Torres MC, Feres-Filho EJ, Colombo AP (2011). Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. J. Clin. Periodontol. 38(4):355-364.
Crossref
 
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Müller HP1, Heinecke A, Borneff M, Kiencke C, Knopf A, Pohl S (1998). Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodotitis. J. Periodontal Res. Jan; 33(1):49-58.
 
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Renvert S, Wikström M, Dahlén G, Slots J, Egelberg J (1990). Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis from periodontal pockets. J. Clin. Periodontol. 17(6):345-350.
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Slots J (2002). Selection of antimicrobial agents in periodontal therapy. J. Periodont. Res. 37:389-398.
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Soleymani SY, Khorsand A, Salary MH, Mehrizy H (2004). Comparison of systemic Ciprofloxacin in elimination of Actinobacillus actinomycetemcomitans from active sites with combination of Metronidazole and Amoxicillin in patients with aggressive periodontitis. A randomized double blind controlled trial. J. Dentistry Tehran Univ. Med. Sci. 1(2):24-28.
 
Tezel A, Yucel O, Orbak R, Kara C, Kavrut F, Yagiz H, Sahin T (2005). The gingival cervicular fluid ciprofloxacin level in subjects with gingivitis and periodontitis, and its effect on clinical parameters. J. Periodont. Res. 40:395-400.
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Tinoco EM, Beldi MI, Campedelli F, Lana M, Loureiro CA, Bellini HT, Rams TE, Tinoco NM, Gjermo P, Preus HR (1998). Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial. J. Periodontol. 69(12):1355-1363.
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Van Winkelhoff AJ, Carolien J (1992). Microbiological and clinical results of Metronidazole plus Amoxicillin therapy in A.a associated periodontitis. J. Periodontol. 63:52-57.
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Yek EC, Cintan S, Topcuoglu N, Kulekci G, Issever H, Kantarci A (2010). Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. J. Periodontol. 81(7):964-974.
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