African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 22 March, 2012; 6(11)

March 2012

Adoption of WHO Standard Operating Procedures for Blood Screening in Hospitals of Islamabad, Pakistan

Author(s): Hasan Abbas Zaheer, Usman Waheed and Yasir Farhan

March 2012

Evaluation of anti-ulcer and antimicrobial effects of Verbena hastata leaf extract

The ulcer protective and antimicrobial effects of the ethanolic leaf extract of Verbena hastata, a popular herbal traditional medicine in southern Nigeria, were assessed using ethanol and indomethacine induced gastric ulcer in rats and against some disease causing microorganisms, respectively. The extract (100-400 mg/kg, p.o) exerted ulcer-protective activities against ethanol and indomethacine-induced...

Author(s): Akuodor G. C., Akpan J. L., Ezeunala Mercy N., Ajoku Gloria A., Essien A. D., Megwas A. U., Okoroafor Dorcas O., Iwuanyanwu T. C. and Osunkwo U. A.

March 2012

Evaluation of antibacterial activity of Morinda citrifolia, Vitex trifolia and Chromolaena odorata

Methanol, ethanol and ethyl acetate extracts of Morinda citrifolia L. (fruit, leaf and stem), Vitex trifolia and Chromolaena odorata (leaf) were prepared to evaluate the anti-bacterial activity. The antibacterial activities of extracts were tested against 12 bacterial isolates by in vitro disc diffusion method. Methanol extracts possessed higher level of antibacterial activity...

Author(s): S. Esath Natheer, C. Sekar, P. Amutharaj, M. Syed Abdul Rahman and K. Feroz Khan

March 2012

Application of obstruction of Glission pedicle combined with partial occlusion obstruction of inferior vena cava in regional liver resection

This study aims to investigate the clinical effect of Glission pedicle obstruction combined with partial obstruction of inferior vena cava in regional liver resection. A total of eight liver cancer patients were retrospectively analyzed. They underwent regional liver resection using a combined method of Glission pedicle obstruction and partial obstruction of inferior vena cava. Among these cases, three...

Author(s): Yahui Liu, Bai Ji, Yingchao Wang and Guangyi Wang

March 2012

Effects of bortezomib on the prognosis of the newly-diagnosed multiple myeloma patients with renal impairment

To analyze the effects of bortezomib on the prognosis of the newly-diagnosed multiple myeloma patients with renal impairment, newly-diagnosed multiple myeloma patients with renal impairment (serum creatinine [Scr] ≥178 μmol/L) were studied in Beijing Chaoyang Hospital. According to the regimen with or without bortezomib, the patients were divided into two groups: bortezomib group (n=25) and non-bortezomib group...

Author(s): Guangzhong Yang, Jing Wang, Lina Fu, Man Shen, Luan Jiang, Yong Zhang, Zhongxia Huang, Wen Gao, Lei Zhang, Yin Wu, Lihong Li and Wenming Chen

March 2012

Protective effect of transplanted bone marrow mononuclearcells (BMMNCs) in organ damage caused due to streptozotocin (STZ) induced diabetes

Diabetes is a rapidly growing health problem; however, there is currently no effective therapy for diabetes. We know that prolonged diabetes leads to damage of various organs apart from pancreas such as kidney and liver and the role of bone marrow mononuclear cells (BMMNCs) is not clearly understood in regeneration of these organs. In this study, we transplanted...

Author(s): Harshit R. Shah##, A. Arivarasan##, Pravir Kumar# and Rashmi K. Ambasta#

March 2012

Potential hepatoprotective effects of vitamin E and selenium on hepatotoxicity induced by malathion in rats

The aim of this present study was to analyze the hepatotoxic effect of malathion in adult male rats and evaluate the possible hepatoprotective effect of vitamin E and/or selenium. Oral administration of malathion for 45 days significantly induced marked hepatic injury as revealed by increased activity of the plasma enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH)...

Author(s): Gaber El-Desoky, Mohammed Abdelreheem, Abdulaziz AL-Othman, Zeid ALOthman, Mohamed Mahmoud, and Kareem Yusuf

March 2012

Scientific evaluation of aqueous extracts of fresh and dried leaves from Rhizophora mucronata lamk (Rhizophoracea) in Rats

The present study investigated the efficacy of fresh and dried leaves extracts of Rhizophora mucronata in experimental animal models and reveals that the fresh leaf extract showed remarkable improvement in the level of counts of red blood cells (RBC), white blood cells (WBC), platelet count, differential count and the level of hemoglobin and packed cell volume (PCV) and also the level of total...

Author(s): M. Babuselvam, K. Kathiresan, S. Ravikumar, M. Uthiraselvam and E. Rajabudeen

March 2012

An ethnobotanical study of medicinal plants used by traditional healers in Durban, South Africa

Medicinal plants have been used extensively for the treatment of infectious diseases by majority of the world’s population. Many of the rural communities in KwaZulu-Natal have no access to western medical healthcare and rely on traditional medicine for their curative properties. It has been noted that approximately 20% of plants found in the world have some pharmacological properties. An ethnobotanical survey of...

Author(s): R. M. Coopoosamy and K. K. Naidoo

March 2012

Immunological and productive responses in male growing white New Zealand rabbits exposed to Diazinon®

Rabbit production plays a considerable role in solving problems of animal protein shortage. This study was conducted to investigate the effect of the dipping of male rabbits in Diazinon on immunological and growth performance. Rabbits were randomly assigned into three equal groups (n=20). Different treatments were administered; control group G1 (dipping in tap water); low dose of Diazinon group G2 (0.60 mg Diazinon in 1...

Author(s): Maha Abdullah Momenah

March 2012

Preparation of carteolol hydrochloride matrix sustained-release pellets and evaluation in vitro/in vivo

The aim of this study was to prepare carteolol hydrochloride matrix sustained-release pellets, and to compare its performance in vivo with carteolol common tablets. The formula was optimized according to the roundness and the release of pellets with single-factor, and orthogonal test. The carteolol hydrochloride matrix sustained-release pellets were got by extrusion-spheronisaion, while the release...

Author(s): H. Zhang, Y. H. Luo, X. Y. Zhao, Q. Chen, M. Luo, L. Y. Luo, C. C. Tian, Z. K. Ge and Y. J. Zhang

March 2012

Evaluation of anti-inflammatory activities of root extracts of Stephania dinklagei (Engl.) Diels

The hexane, chloroform, ethyl acetate and methanol extracts of Stephania dinklagei were screened for anti-inflammatory activities using carrageenan, kaolin-carrageenan and formaldehyde-induced paw edema models of inflammation. The extracts showed dose dependent anti-inflammatory activity with 300 mg/kg of the extracts being more potent. At 1 and 4 h, post carrageenan injection, the paw edema in the 100 and 300...

Author(s): Rita I. Udegbunam, Obinna K. Nwamkpa, Sunday O. Udegbunam, Chinaka O. Nwaehujor and Gregory E. Offor

March 2012

Salvianolic acid B inhibits matrix metalloproteinases by NF-κB signaling in rabbit chondrocytes

This study investigates the chondroprotective properties of Salvianolic acid B (Sal B) in interleukin (IL)-1β-induced rabbit chondrocytes. Quantitative real-time PCR, enzyme-linked immunosorbent assay (ELISA) and western blot were performed to investigate the effects of Sal B on the mRAN and protein levels of matrix metalloproteinases (MMP)-1, MMP-3, MMP-13, tissue inhibitors of metalloproteinase-1 (TIMP-1) and...

Author(s): Yan-Xiong, Wei-Ping Chen, Jing-Li Tang, Jia-Peng Bao, Peng-Fei Hu and Li-Dong Wu

March 2012

Screening of central nervous system (CNS) depressant and antinociceptive activities of methanolic extracts of the peel and seed of Nephelium longan fruits

In recent years, research on medicinal plants has engrossed a lot of interest worldwide. Large body of proof has been accumulated to reveal promising potential of medicinal plants used in different traditional, complementary and alternative systems. Keeping this in mind, the present study was carried out to scrutinize the antinociceptive and central nervous system (CNS) depressant activity of the methanol extracts of...

Author(s): Farhana Alam Ripa, Mahmuda Haque, Israt Jahan Bulbul, Afsana-Al-Sharmin, Yesmin Begum and Afroza Habib

March 2012

In vitro antioxidant, total phenolic content and preliminary toxicity studies of Gmelina philippensis chem.

Investigation with the crude methanol extract of leaves and flowers of Gmelina philippensischem. as well as petroleum ether, carbon tetrachloride and dichloromethane soluble partitionates were carried out to evaluate antioxidant activity. It was evaluated by analyzing the bleaching rate of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and phosphomolybdenum total antioxidant assay using, butylated hydroxytoluene (BHT)...

Author(s): Sharmin Reza Chowdhury, Farhana Islam,Tasdique Mohammad Quadery, Mahbubul Hoque Shihan and Mohammad A. Rashid

March 2012

Effect of Angelica sinensis aqueous extract on uterus, ovary NF-kB/β-actin and IL-6/β-actin mRNA expression level in pelvic inflammation model rats

Angelica sinensis is a Chinese medicinal herb for treating gynecological and gastrointestinal disorders and also in conjunction with cancer chemotherapy. In the present study, the effects of A. sinensis aqueous extract on uterus, ovary NF-kB/β-actin and IL-6/β-actin mRNA expression level in Pelvic inflammation model rats were investigated. Results showed that A. sinensis aqueous...

Author(s): Chunyan Huang, Xiaoping Chen, Hongmei Liu, Xinping Ren and JinLing Xue