Abstract

This work is a prospective study that aims to evaluate the vitamin D status of Moroccan women during the last trimester of their pregnancy to establish the prevalence of hypovitaminosis D. We carried out, within the Mohammed V Military Teaching Hospital (HMIMV), a six-month prospective study on the vitamin status D of 152 Moroccan women during their last gestational trimester. Maternal blood was collected at the Gynecology-Obstetrics Department during the last prenatal visit or during the delivery process. Serum assays for 25 (OH) D3, PTH, calcium, phosphorus and PAL were performed in the HMIMV Biochemistry Laboratory. A questionnaire was developed to reveal different parameters influencing vitamin status. The vitamin D deficiency rate is very high in our study sample. We found 97.37% hypovitaminosis D (<30 ng / ml) of which 9.21% in insufficiency ([20-30] ng / ml), 88.16% in deficiency (<20 ng / ml). Statistical analysis shows no correlation between age and vitamin concentration (p = 0.933). We found a negative correlation between 25 (OH) D3 and parathormone (PTH) (p = 0.016, r = - 0.194) and observed a variation of 25 (OH) D3 according to the sun, the BMI and the pigmentation of the skin although no statistical relationship has been established. There is no association between physical activity and 25 (OH) D3 concentration (p = 0.331). We recommend the implementation of corrective measures that focus on vitamin D information campaigns. The pregnant woman should be encouraged to receive adequate nutrition and a balanced diet.

Keys words: 25-hydroxy-vitamin D3, calciferol, pregnancy, hypovitaminosis D.