Full Length Research Paper
Abstract
The aim of this study is to assess the risk of hepatitis B transfusion in negative HBsAg blood donors who test positive for anti HBcAb. From January to December 2019, an observational study of virological markers was carried out with blood donors (family and volunteers) at the National Blood Transfusion Center in N’Djamena. The donors included were also tested negative for the markers (Ab anti HCV, HIVAg/Ab and TPHA) according to standard methods of clinical microbiology. Of the 1106 donors included in this study, we determined a positivity rate of 41% of anti HBcAb. Significant differences were observed between the proportions of donors: Family (77.48%) and volunteers (22.51%), positive for anti HBcAb (41%) and negative (59.13%), male sex (72%) and female (28.09%) with probabilities of 0.01, 0.001 and 0.001, respectively. This survey made it possible to determine an elevated level of HBcAb in the study population and also to determine about ten cases of cirrhotic patients negative for HBsAg and positive for HBcAb. In view of this result, it is recommended to complete in blood donors with negative HBsAg and HBcAb carriers, screening for anti-HBsAb and, if possible, quantify the viral B DNA in order to minimize the risk of residual hepatitis B transmission among these blood donors in Chad.
Key words: Anti-HBc antibodies, seroprevalence, blood donors, hepatitis B, N’Djamena.
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