African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Hydrogen 1 (1H) magnetic resonance spectroscopy (MRS) of 3.0T in assessment of steatosis to antiviral therapy for chronic hepatitis C

Qian Zhang#
  • Qian Zhang#
  • Department of Digestive, China-Japan Union Hospital affiliated to Jilin University, 126 xiantai BLVD, Changchun, Jilin Province, P. R. China.
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Yonggui Zhang#
  • Yonggui Zhang#
  • Department of Digestive, China-Japan Union Hospital affiliated to Jilin University, 126 xiantai BLVD, Changchun, Jilin Province, P. R. China.
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Chunyu Zhang
  • Chunyu Zhang
  • Department of Radiology, 1st Hospital affiliated to Jilin University, Changchun, Jilin Province, P. R. China.
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Ping Zhao
  • Ping Zhao
  • Department of Digestive, China-Japan Union Hospital affiliated to Jilin University, 126 xiantai BLVD, Changchun, Jilin Province, P. R. China.
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Jian Jiao
  • Jian Jiao
  • Department of Digestive, China-Japan Union Hospital affiliated to Jilin University, 126 xiantai BLVD, Changchun, Jilin Province, P. R. China.
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Jiangbin Wang*
  • Jiangbin Wang*
  • Department of Digestive, China-Japan Union Hospital affiliated to Jilin University, 126 xiantai BLVD, Changchun, Jilin Province, P. R. China.
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  •  Received: 14 November 2014
  •  Accepted: 08 December 2014
  •  Published: 31 December 2014

Abstract

This study investigates the utility of Hydrogen 1 (1H) magnetic resonance spectroscopy as a noninvasive test for steatosis of response to interferon and ribavirin treatment in patients developing different severity of hepatitis C virus (HCV). Ninety chronic hepatitis C patients undergoing antiviral therapy with interferon and ribavirin underwent 1H MR spectroscopy at 3.0T before treatment, 6 month after the start of treatment and one year after the start of treatment. Peak value of lipid, area under the peak of lipid, peak ratio of lipid, water and area ratio under the peak of lipid, water statistical difference between baseline of control group and antiviral group, and also between baseline and after the start of therapy 6 month of antiviral therapy group. 1H MRS is a noninvasive technique that can be used to provide liver steatosis information on hepatic metabolic processes. This study indicates that the 1H MRS can be used as an indicator of steatosis response to antiviral treatment in chronic hepatitis C patients.
 
Key words: Hydrogen 1 (1H), magnetic resonance spectroscopy (MRS), hepatitis C, antiviral therapy. 
 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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