African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12481

Full Length Research Paper

Serum insulin-like growth factor-I adult reference values for an automated chemiluminescence immunoassay system

    Denise Boechat Leite1*, Ricardo Martins-da-Rocha Meirelles1, Carlos Alberto Mandarim-de-Lacerda2, Haroldo José de Matos3 and Mario Bernardo-Filho4  
    1Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione and Programa de Pós-graduação em Ciências Médicas, Universidade do Estado do Rio de Janeiro, Brazil. 2Laboratório de Morfometria, Metabolismo e Doença Cardiovascular, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. 3Departamento de Tecnologias da Informação e Educação em Saúde, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. 4Departamento de Biofísica e Bioemtria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.    
Email: [email protected]

  •  Accepted: 17 October 2011
  •  Published: 07 December 2011

Abstract

 

Analysis of insulin-like growth factor I (IGF-I) in serum is fundamental in order to aid in the diagnosis of growth hormone (GH)-related disorders, as well as in the diagnosis and follow-up of other diseases. Considering the importance of IGF-I local normal range, the aim of this study was to determine reference values for IGF-I (Immulite 2000) in a Brazilian adult population from the city of Rio de Janeiro. This study included samples of blood taken from 484 healthy subjects (251 men, 233 women) aged 18 to 70. The subjects agreed with this study, approved by the ethical committee of the Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti,Rio de Janeiro, Brazil. The samples were analyzed by an automated immunochemiluminometric assay (ICMA). For data analysis, age and sex-specific figures were fitted after transformation of IGF-I values. In adulthood, a slow age-dependent decrease was seen. IGF-I in women were significantly higher than in men.The present study established age- and sex-specific IGF-I reference values, for the healthy Brazilian adult populatoin from the city of Rio de Janeiro, determined with the currently most widely IGF-I assay used in Brazil (Immulite 2000).

 

Key words: Insulin-like growth factor I, chemiluminescence assay, reference range.

Abbreviation

Abbreviations: IGF-I, Insulin-like growth factor I; GH, growth hormone; ICMA,immunochemiluminometric assay.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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