African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12488

Full Length Research Paper

Multiple protein-domain conservation architecture as a non-deterministic confounder of linear B cell epitopes

Misaki Wayengera
  • Misaki Wayengera
  • Unit of Genetics and Genomics, Departments of Pathology and Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University P.O Box 7072 Kampala, Uganda.
  • Google Scholar


  •  Received: 06 September 2014
  •  Accepted: 06 August 2015
  •  Published: 12 August 2015

References

Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997).Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.
Crossref
 
Batada NN, Hurst LD, Tyers M (2006). Evolutionary and physiological importance of hub proteins. Plos Comput. Biol. 2(7): e88.
Crossref
 
Bruce C, Clegg C, Featherstone A, Smith J, Oram J (1993). Sequence analysis of the gp120 region of the env gene of Ugandan human immunodeficiency proviruses from a single individual. AIDS Res. Hum. Retrovir. 9 (4):357-363.
Crossref
 
Chou PY, Fasman GD (1978) Prediction of the secondary structure of proteins from their amino acid sequence. Adv. Enzymol. Relat. Areas Mol. Biol. 47:45-148.
PMid:364941
 
Emini EA, Hughes JV, Perlow DS, Boger J (1985). Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol. 55(3):836-839.
Pubmed
 
Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW (2002). Evolutionary Rate in the Protein Interaction Network. Science 296:750-752
Crossref
 
Geer LY, Domrachev M, Lipman DJ, Bryant SH (2002). CDART: protein homology by domain architecture. Genome Res. 12(10):1619-623.
Crossref
 
Haste Andersen P, Nielsen M, Lund O (2006). Prediction of B-cell epitopes using protein 3D structures. Protein Sci. 15(11): 2558-2567.
Crossref
 
Huang J, Honda W (2006). CED: a conformational epitope database. BMC Immunol. 7: 7
Crossref
 
Karplus PA, Schulz GE (1985). Prediction of Chain Flexibility in Proteins - A tool for the Selection of Peptide Antigens. Naturwissenschafren. 72: 212-213.
Crossref
 
Kolaskar AS, Tongaonkar PC (1990). A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 276(1-2):172-174.
Crossref
 
Korber B, LaBute M, Yusim K (2006). Immunoinformatics comes of age. PLoS Comput Biol. 2(6): e71.
Crossref
 
Labrosse B, Morand-Joubert L, Goubard A, Rochas S, Labernardière JL, Pacanowski J, Meynard JL, Hance AJ, Clavel F, Mammano F(2006). Role of the envelope genetic context in the development of enfuvirtide resistance in human immunodeficiency virus type 1-infected patients. J. Virol. 80(17):8807-8819.
Crossref
 
Larsen JE, Lund O, Nielsen M (2006). Improved method for predicting linear B-cell epitopes. Immunome Res. 2:2.
Crossref
 
Liu Y, Woodward A, Zhu H, Andrus T, McNevin J, Lee J, Mullins JI, Corey L, McElrath MJ, Zhu T (2009). Preinfection human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes failed to prevent HIV type 1 infection from strains genetically unrelated to viruses in long-term exposed partners. J. Virol. 83 (20): 10821-10829.
Crossref
 
Marchler-Bauer A, Lu S, Anderson JB, Chitsaz F, Derbyshire MK, DeWeese-Scott C, Fong JH, Geer LY, Geer RC, Gonzales NR, Gwadz M, Hurwitz DI, Jackson JD, Ke Z, Lanczycki CJ, Lu F, Marchler GH, Mullokandov M, Omelchenko MV, Robertson CL, Song JS, Thanki N, Yamashita RA, Zhang D, Zhang N, Zheng C, Bryant SH(2011). CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res. 39(Database issue): D225-229.
Crossref
 
Parker JM, Guo D, Hodges RS (1986). New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites. Biochemistry 25(19): 5425-5432.
Crossref
 
Sanchez A, Kiley MP, Holloway BP, Auperin DD (1993). Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus. Virus Res. 29: 215-240.
Crossref
 
Sanchez A, Lukwiya M, Bausch D, Mahanty S, Sanchez AJ, Wagoner KD, Rollin PE (2004). Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J. Virol. 78: 10370-10377.
Crossref
 
Sanchez A, Trappier SG, Mahy BW, Peters CJ, Nichol ST (1996). The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc. Natl. Acad. Sci. U.S.A. 93:3602-3607.
Crossref
 
Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, Söding J, Thompson JD, Higgins DG (2011). Fast, scalable generation of high-quality protein multiple sequence alignments using clustal omega. Mol. Syst. Biol. 7:539.
Crossref
 
Zhang Q, Wang P, Kim Y, Haste-Andersen P, Beaver J, Bourne PE, Bui HH, Buus S, Frankild S, Greenbaum J, Lund O, Lundegaard C, Nielsen M, Ponomarenko J, Sette A, Zhu Z, Peters B (2008). Immune epitope database analysis resource (IEDB-AR). Nucleic Acids Res. 36(Web Server issue):W513-518.