African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 421

AJBR Articles

Tomato supplement ameliorates castration-induced oxidative stress in the rat

April 2013

  Castration has previously been shown to induce oxidative stress. Previous studies have shown tomato to be a potent anti-oxidant which reduces oxidative stress in many disease conditions. However, the likely role of tomato in ameliorating castration-induced oxidative stress has not been studied and was of interest to us. The present study looked into the effect of tomato supplement on the plasma level of...

Author(s): Ayobami Oladele Afolabi, Oluwatosin Oluwaseun Osho and Isiaka Abdullateef Alagbonsi

Comparative osmotic fragility of three erythrocyte genotypes (HbAA, HbAS and HbSS) of male participants administered with five antimalarial drugs

March 2013

n vivo study was carried out to ascertain the mean corpuscular fragility (MCF) index and corresponding stability of three erythrocyte genotypes (HbAA, HbAS and HbSS) before (control; t = 0 h) and after (tests; that is, at t = 3, 6 and 18 h) five (5) antimalarial drugs (FansidarTM, HalfanTM, Quinine, CoartemTM, and Chloroquine phosphate) were administered to male participants. Clinically confirmed healthy...

Author(s): P. C. Chikezie, A. A. Uwakwe and C.C. Monago

Nutrigenomic studies of orange juice and vitamin c on gene expressions in neuronal tissues of Sprague Dawley rats

February 2013

  Nutrigenomics, a nascent field in nutrition and molecular biology plays a pivotal role in understanding the influence of bioactive dietary components on the structure, integrity and functions of the genome. In this study, the comparative effects of vitamin C (Vit C) and Nigerian local orange juice on the gene expression levels of superoxide dismutase (sod), tumour necrosis factor receptor...

Author(s): Osaretin Albert T.  Ebuehi, Yusuf Salami, Ayorinde B. James and Imelda N. Mgbeadichie

Oxalate metabolism by Sclerotinia sclerotiorum, a fungal pathogen in soybeans

February 2013

  Pathogenesis of Sclerotinia sclerotiorum mainly depends on production of oxalate (Lib.) de Bary, but the mechanism by which the oxalate is produced is not well understood. Control of Sclerotinia stem rot (SSR) in soybean which is caused by this ubiquitous phytopathogenic fungus requires the knowledge of oxalate synthesis by S. sclerotiorum. Nine isolates from infected soybeans and soils were...

Author(s): Mbiri A., Gatebe E., Ndung’u M., Kariuki W. and Mwangi E.

Serum ghrelin levels in Syrian obese patients with diabetes mellitus type II

January 2013

  The serum ghrelin levels had been studied in three groups of subjects׃ First group was normal weight (11 men and 9 women), non obese, non diabetic, 38 ± 12 years old, with BMI mean about 23.8 kg/m2 and did not take any drugs. The second group was overweight (18 men and 13 women), non diabetic, 40.6 ± 9.9 years old, with BMI mean about 36.34 kg/m2. This group was apparently healthy and...

Author(s): Moayad A. Saad, Younes M. Kabalan and Faizah A. Al-Quobaili

Plasma concentration of acylated ghrelin in patients with Alzheimer’s disease

January 2013

  Ghrelin is a hormone produced in the stomach and tightly linked to the regulation of energy balance and cognitive processes. It may be altered in Alzheimer’s disease (AD), a dementia syndrome markedly influenced by metabolic diseases. The aim of this study was to evaluate the changes in the plasma concentration of acylated ghrelin in patients with AD. The study included 71 people 37 in the case...

Author(s): Akbarzadeh S, Yusefi F, Jafari SM, Khosravizadegan F, Moula A, Salimipour H, Eghbali SS, Motamed N, Hajian N, Rahbar A, Abdi MR, Hazrati S and Movahed A

Assessment of the potency of some selected anti-malaria drugs on the supplements of vitamin B2 and orange fruit juice (combination therapy)

December 2012

Current practice in treating cases of malaria is based around the concept of combination therapy, since this offers several advantages - reduced risk of treatment failure, reduced risk of developing resistance, enhanced convenience and reduced side-effects. The effect of the supplements vitamin B2 (Riboflavin) and orange fruit juice on the potency and efficacy of some selected anti-malaria drugs (Armact, Coartem, Waipa...

Author(s): Adumanya O. C., Uwakwe A. A., Odeghe O. B., Essien E. B. and Okere T. O.

Effects of Emilia praetermissa leaf extract on the haematological and biochemical parameters of stress induced ulcerated Wistar rats

December 2012

Effects of Emilia praetermissa leaf extract on the haematological and biochemical parameters of cold-water stress induced ulceration in albino rats were the focus of this study. Blood samples collected from stress induced ulcerated Wistar rats by cold water immersion were used to evaluate the haematological and biochemical parameters. This study was conducted using twenty rats randomly divided into four...

Author(s): A. O. Ebunlomo, A. O. Odetola, O. Bamidele, J. N. Egwurugwu, S. Maduka and J. Anopue

A Biflavonoid and a Carotenoid from Rhus leptodictya: Isolation, Characterization and Antibacterial Properties

November 2012

Acetone extracts of the leaves of Rhus Leptodictyawere studied for antibacterial activity usingbioautography and micro titre plate assay techniques against four nosocomial bacterial pathogens - Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, andEnterococcus faecalis. A bioassay guided fractionation showed that the activity was concentrated in the carbon tetrachloride fraction. A...

Author(s): Songca SP, Sebothoma C, Samuel BB and Eloff JN

Antioxidant screening of ethanolic and aqueous extracts of Organum vulgare L. in-vitro

November 2012

The present study was envisaged to assess the rationality for the use of traditionally invogue herb Organum vulgare as an anti-oxidant agent. Potential antioxidative activity of O. vulgare was evaluated using various in vitro methods including post mitochondrial supernatant (PMS) and microsomal lipid peroxidation, DNA sugar damage, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical...

Author(s): Rubina Majid, Latief Ahmad and M. A. Zargar

Measurement of cholesterol sub-fractions, high density lipoprotein 2 and high density lipoprotein 3, in HIV infected patients treated with highly active antiretroviral therapy in Burkina Faso

October 2012

This paper described dyslipidemia caused by the metabolic effects of HIV and exposure to antiretroviral therapy. The aim of this study was to appreciate the interest of the measurement of HDL sub-fractions in the monitoring of human immunodeficiency virus (HIV) infected patients on antiretroviral treatment. A case-control study was carried out on 31 HIV infected before (naive) highly active antiviral therapy (HAART...

Author(s): Jean Sakandé, Josiane B Kaboré, Elie Kabré, Boblwendé Sakandé and Mamadou Sawadogo

Effects of methanol extract of Vernonia amygdalina leaf on survival and some biochemical parameters in acute Trypanosoma brucei brucei infection

October 2012

The effects of methanol extract of Vernonia amygdalina leaf (chosen from several extracts tested) on survival, parasitaemia, packed cell volume and some biochemical parameters were investigated in acute Trypanosoma brucei brucei infection. Results showed that the extract was relatively safe with median lethal dose, LD50 ≥5000 mg/kg/day. Although none of the extracts tested cured infected...

Author(s): Yusuf, Aminu Bashir, Umar, Ismail Alhaji and Nok, Andrew Jonathan

Heavy metals distribution and lipid profile in the stomach of cow grazed in Akungba-Akoko, Ondo State, Nigeria

June 2012

The distribution of heavy metals: manganese, chromium, cadmium, copper, arsenate, iron and lead together with lipid profiles were investigated in the stomach of cow grazed in Akungba-Akoko region of Ondo State, Nigeria. This sample was analyzed using Atomic Absorption Spectrophotometric method (AAS) with wet digestion method. The results showed that the heavy metals concentrations in the stomach of the cows are: Mn...

Author(s): Elekofehinti O. O., Omotuyi I. O., Olaremu A. G. and Abayomi T. G.

Heavy metals distribution and lipid profile in the stomach of cow grazed in Akungba-Akoko, Ondo State, Nigeria

June 2012

Essential oils were obtained by hydro distillation of dried leaves from two kinds of Plectranthus tenuicaulis (Hook f.) J. k. Morton grown in Gabon and were analyzed using GC-FID, GC-MS, 1H and 13C NMR. The main constituent was (R), (E)-6,7-epoxyocimene [(E)-myroxide] (72.2 to 83.8%) with small amounts of (Z)-6,7-epoxyocimene (0.6 to 1.3%), (E) and (Z)-β-ocimene (1.1 to...

Author(s): Bikanga Raphaël, Obame-Engonga Louis-Clément, Agnaniet Huguette, Makani Thomas, Anguile Jean Jacques, Lebibi Jacques, and Menut Chantal

Intraspecific diversity of Egyptian and foreign new lines of chickpea based on Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and isozyme markers

May 2012

Four Egyptian and 21 foreign new lines of kabuli chickpea (Cicer arietinum L.) were analyzed by using biochemical molecular markers to gain insight into the genetic diversity between accessions. Polyacrylamide gel electrophoresis (PAGE) was applied on the total soluble seed proteins by using sodium dodecyl sulphate (SDS) and five isozyme systems to examine the storage and functional components, respectively. The storage...

Author(s): Maged Mahmoud Abou-El-enain and Shawkat Mahmoud Ahmed

Thermogenic response of guinea pig adipocytes to noradrenaline and β3-AR agonists

May 2012

Brown adipocytes isolated from warm acclimated guinea pig do not respond to noradrenaline (NA) in spite of their marked thermogenic response in vivo. In contrast, in cold-acclimated guinea pigs, isolated brown adipocytes show substantial increase in capacity for a thermogenic response to NA. Chronic stimulation with a β3-AR agonist increased insulin-sensitivity of brown adipose tissue (BAT) in the guinea pig....

Author(s): Ghorbani Masoud and Mehdi Shafiee Ardestani

Effect of certain insect growth regulators on the lipid content of some tissues of the desert locust Schistocerca gregaria

May 2012

The present study was carried out to investigate the metabolic effects of pyriproxyfen, tebufenozide or lufenuron on the lipid content in two different tissues: hemolymph and fat body of the early-, mid- and late-aged old nymphs as well as 1- and 4-days old adult females. Hemolymph lipid content of the early-aged nymphs had been subjected to a reducing effect after treatment with high concentration of insect growth...

Author(s): Hamadah Kh.Sh., Ghoneim K.S. and Tanani M.A.

In vitro anthelmintic potentials of Xylopia aethiopica and Monodora myristica from Nigeria

May 2012

Monodora myristica and Xylopia aethiopica are two spices that have been traditionally used as a vermifuge in Ayurveda. The main aim of the research work was to investigate the phytochemical constituents of the aqueous, ethanol and methanol extracts of the two spices and the anthelmintic activity of the extracts of their seeds against Eudrilus eugeniae. The four concentrations (10, 20, 50 and 100...

Author(s): Ekeanyanwu R. C. and Etienajirhevwe O. F.

Effect of boiling on the phytochemical constituents and antioxidant properties of African pear Dacryodes edulis seeds in vitro

April 2012

  African pear, Dacryodes edulis, seed extract has been used for the treatment of ailments in traditional medicine. However, the effect of boiling on its antioxidant properties is still poorly understood. Therefore, the present study investigates the effect of boiling on the antioxidant properties of D. edulis seed extract using in vitro parameters such as free radical scavenging ability against 2, 2- diphenyl...

Author(s): T. Ogunmoyole, I. J. Kade, O. D. Johnson and O. J. Makun

In-vitro assessment of antioxidant potential and phenolic capacity of Temnocalyx obovatus leaves

April 2012

Temnocalyx obovatus is widely found in many areas in Zimbabwe, Nigeria and Zambia where it is used to treat a variety of ailments. Phenolic compounds in T. obovatus assessed by Folin-Ciocalteu method varied from 1.18 to 2.89 mg tannic acid g-1. Acetone extract showed the greatest flavonoids, flavonols and proanthocyanidins content 5.12, 4.13 and 3.07 mg catechin g-1respectively. 2,...

Author(s): P. Dzomba, E. Togarepi and C. Mahamadi

Toxicological investigation of aqueous leaf extract of Calotropis procera (Ait.) R. Br. in Wister albino rats

April 2012

The pathological changes due to the oral administration of the aqueous extract of the leaves ofCalotropis procera were studied in rats over a period of sixty days. The leaf extract was administered orally to rats in three groups receiving doses of 500, 1000 and 1500 mg/kg. The fourth group served as a control and received distilled water only. Result showed that, oral administration of the aqueous extract...

Author(s): Mohammed A., Ibrahim S. I. and Bilbis L. S.,

Effect of vitrifying solutions, ethylene glycol and 1, 2-propandiol, on intracellular K+ and lactate dehydrogenase (LDH) of hepatocytes in primary culture

April 2012

Shortage of donor liver tissue for the isolation of hepatocytes requires the development of improved cryopreservation techniques for long-term storage of these cells for more efficient use. The aim of this study is to compare two cryoprotectants for preserving living cells in culture by vitrification. The viability of hepatocytes after cryopreservation was determined by the intracellular concentration of potassium...

Author(s): Diallo Mouhamadou, Nguer Cheikh Momar, Gueye Papa El Hadji Omar, Ndongo Souhaibou, Sarr Ousmane and Mboup Souleymane

Chemical composition and in vitro antioxidant, cytotoxicity activities of Zingiber officinale Roscoe essential oil

March 2012

This study was designed to examine the in vitro antioxidant and cytotoxicity activities of Zingiber officinale Roscoe (ginger) rhizome essential oil. GC-MS analysis of the essential oil resulted in the identification of 7 compounds, representing 90.06% of the oil, the major constituents were described as α-zingiberene (52.35%), β-pinene (14.20%) and β-sesquiphellandrene (12.11%). The...

Author(s): Wei Wang, Lin Zhang, Nan Li, and Yuangang Zu,

Effects of harvest time and cultivar on yield and physical properties fibers of kenaf (Hibiscus cannabinus L.)

March 2012

Kenaf (Hibiscus cannabinus L.) is an annual non wood plant which has shown great potential as an alternative source of papermaking fiber. No information is available on kenaf cultivation in south-Iran in spite of the need to replace imported long fibers through local production of alternative sources. The purpose of this research is to investigate the effect of kenaf cultivars and harvest times on component yield...

Author(s): Jalal Shakhes, Farhad Zeinaly, Morteza A. B Marandi and Tayebe Saghafi

Antioxidant capacity of bioactive compounds extracted from selected wild and domesticated cereals of Zimbabwe

March 2012

Bioactive compounds were extracted from 6 wild and 4 domesticated cereal grains of Zimbabwe, using 50% methanol with the aim of testing their capability to prevent phospholipid peroxidation and β-carotene bleaching. The highest yield of phenolic compounds was obtained from Eleusine indica (a wild cereal) with 7.16 mg GA/100 mg sample, while the least yield was obtained from Amaranthus...

Author(s): Kudakwashe Chitindingu, Jill J. F. Chitindingu, Mudadi A. N. Benhura, Amos Marume, Isaac Mutingwende, Michael Bhebhe and Maud Muchuweti

Levels of matrix metalloproteinases (MMPs) in tear fluid of mustard gas exposed patients with chronic dry-eye symptoms

March 2012

The purpose of this study is to compare the levels of MMP-1, 2, 8, 9 in tear fluids of people exposed to mustard gas in the war between Iraq and Iran who had the chronic dry-eye symptoms compared to the normal group. In this study, 25 of the patients who were exposed to mustard gas and had chronic dry eye symptoms were compared to 25 patients as control group; consisting of 25 people who had common chronic dry eye...

Author(s): Reza Haji Hosseini and Malek Ashtar Esfandiary

Unutilized energy reserves and mineral contents of fibroid tissues suggesting perturbed membrane transport processes

February 2012

Compositions of intramural uterine fibroid (IUF) and subserous uterine fibroid (SUF) tissues were studied. Results showed that IUF and SUF, respectively, contained (%) 77.26 ± 0.05 and 77.49 ± 0.02 moisture and 22.74 ± 0.05 and 22.52 ± 0.02 dry matter, on wet-weight basis. Their respective moisture, crude fat, crude protein, ash and total carbohydrates (%) were 4.67 ± 0.05 and 4.38...

Author(s): Ibegbulem C. O., Agha N. C. and Emeka-Nwabunnia I.

Effect of essential oil of the leaves of Eucalyptus globulus on heamatological parameters of wistar rats

February 2012

The study was designed to evaluate the effect of essential oil extract of Eucalyptus globulus on haematological parameters of wistar rats. Twenty-five adult wistar rats weighing between 80 to 130 g were used. The rats were divided into five groups; with group one as the control group. Increasing doses (12.5, 25.0, 50.0, 72.5 mg/ml) of the extract were administered orally daily to the other four groups for a...

Author(s): OYESOMI, Tajudeen Oyesina, AJAO, Moyosore Salihu, OLAYAKI, luquman Aribidesiand ADEKOMI, Damilare Adedayo

Bacteriological characterization of snacks sold in Rivers State University of Science and Technology, Port Harcourt, Nigeria

February 2012

Two types of pastry snacks (Moin-moin and Buns) were bought from four different hawkers in the Rivers State University of Science and Technology, Port Harcourt, from four locations viz. Student Residential area, Faculty of Science, Faculty of Engineering and the Old Administrative area. Ten representative bacterial isolates from each of the snacks from the locations were tentatively identified separately from...

Author(s): Lovet T. Kigigha and Henry C. Uge

Comparative phenolic profile of Persian walnut (Juglans regia L.) leaves cultivars grown in Iran

February 2012

In this study Walnut leaves from 11 different cultivars (Mayette, Fernor, Mellanaise, Elit, Orientis, Lara, Hartley, Franquette, Parisienne, Arco and Marbot) were studied for their phenolic compounds. The evolution of major phenolic compounds amounts was monitored from May to September. Two extractive procedures were assayed and the best results were obtained using acidified water (pH 2) and a solid phase...

Author(s): Amir Jalili and Asra Sadeghzade

Maternal oxidative stress and enzymatic antioxidant status in premature rupture of membranes

January 2012

Premature rupture of the fetal membrane is a major cause of preterm birth and it is associated with infant morbidity. To examine the relationship between maternal oxidative stress (OS) and antioxidant statue and premature rupture of membranes (PROM). 30 pregnant women with PROM and 30 normal pregnant women were compared for maternal malonaldihyde concentration, erythrocyte glutathione (GSH) concentration, glutathione...

Author(s): Jafar Maleki, Ladan Haghighi, Mohsen Korani, Soudabeh Fallah, Mohsen Firozrai and Morteza Seifi

The significance of artemisinin in roll back malaria partnership programmes and cancer therapy

January 2012

The role of the natural product, artemisinin, is discussed, with a view to elucidating its importance as an antimalarial, essential to sustainable global development, especially in the health and welfare industry. An estimated 243 million cases of malaria led to an estimated 863,000 deaths in 2008. The Roll Back Malaria (RBM) Partnership is a global network for co-ordinated action against malaria, launched in 1998 by...

Author(s): Obimba, Kelechukwu Clarence

Matrix metalloproteinases activity in fibrosarcoma Wehi-164 cells

January 2012

Fibrosarcoma is a malignant disorder of fibroblasts and extremely metastatic cancer. Angiogenesis plays an important role in metastasis. Several factors including matrix metalloproteinases (MMPs) involve in angiogenesis. MMPs are a large group of endopeptidases which degredate the extracellular matrix. The present study was conducted to evaluate the patterns of MMP-2/MMP-9 activity in Wehi-164 cells in vitro....

Author(s): Fatemeh Hajighasemi and Fatemeh Rezaeian

Effect of electromagnetic field on acetylcholinesterase activity: In vitro study

January 2012

The in vitro effects of extremely low frequency (ELF)-electromagnetic field (EMF) (frequencies of 50, 100, 217 Hz, induction 300 µT) on the structure and activity of acetylcholinesterase (AChE) was investigated. AChE activity was measured with UV-vis spectroscopy. Circular dichroism spectroscopy and fluorescence spectroscopy were used for investigating the secondary and tertiary structure of enzyme. The...

Author(s): Ezzatollah Fathi and Raheleh Farahzadi

Maternal oxidative stress and enzymatic antioxidant status in premature rupture of membranes

January 2012

Premature rupture of the fetal membrane is a major cause of preterm birth and it is associated with infant morbidity. To examine the relationship between maternal oxidative stress (OS) and antioxidant statue and premature rupture of membranes (PROM). 30 pregnant women with PROM and 30 normal pregnant women were compared for maternal malonaldihyde concentration, erythrocyte glutathione (GSH) concentration, glutathione...

Author(s): Jafar Maleki, Ladan Haghighi, Mohsen Korani, Soudabeh Fallah, Mohsen Firozrai and Morteza Seifi

The significance of artemisinin in roll back malaria partnership programmes and cancer therapy

January 2012

The role of the natural product, artemisinin, is discussed, with a view to elucidating its importance as an antimalarial, essential to sustainable global development, especially in the health and welfare industry. An estimated 243 million cases of malaria led to an estimated 863,000 deaths in 2008. The Roll Back Malaria (RBM) Partnership is a global network for co-ordinated action against malaria, launched in 1998 by...

Author(s): Obimba, Kelechukwu Clarence

Screening of antioxidant activity, total phenolics and gas chromatography-mass spectrophotometer (GC-MS) study of ethanolic extract of Aporosa lindleyana Baill

December 2011

The present study was carried out for the identification of phytochemicals present in the roots ofAporosa lindleyana and also to evaluate the total phenol, total flavonoids and antioxidant activity. Total phenol was carried out by Folin Ciocalteu method and the phenolic content was 31.20 mg/100 g of gallic acid equivalent (GE) and the flavonoid content was 203.10±0.9. Antioxidant activity was evaluated by...

Author(s): S. Ramakrishnan and R. Venkataraman

Alterations in the biochemical components and photosynthetic pigments of mulberry (Morus Spp.) attacked by leaf – roller (Diaphania pulverulentalis) pest

December 2011

Leaf roller (Diaphania pulverulentalis Hampson) is a serious pest of mulberry (Morus alba L.), which is the sole food for silkworm – Bombyx mori L. It attacks the tender leaves of the host causing considerable damage which alters the leaf quality. An attempt was made to know the changes in the biochemical components (free amino acids, total soluble proteins, total reducing sugars, total soluble...

Author(s): A. Mahadeva and V. Nagaveni

The apoptotic and cytotoxic effects of Polygonum avicular extract on Hela-S cervical cancer cell line

December 2011

Cervical cancer is the second main cause of cancer leading death in women. Therefore, targeting it, preferably with natural compounds derived from medicinal plant such as Polygonum avicular as an herbal extract have astringent properties. Herbal medicines in all regions of the developing world are widely used. Unlike the heavy use, there are very little information about the health and efficiency of the treatment by...

Author(s): Rahmati Mohammad, Bannazadeh Hossein, Fazli Davood, Tahmasebzadeh Farnaz, Farrokhi Ali and Rasmi Yusef

Dyslipidemic and atherogenic effects of academic stress

November 2011

Evidence suggests that there is strong relationship between stress and development of cardiovascular disorders. Here, the relationship between academic stress and selected traditional markers of cardiovascular disorder such as lipids and lipoprotein profile and apoproteins were investigated. Eighty apparently healthy male and female students participated in the study. Plasma concentration of selected biochemical...

Author(s): Adekunle Adeniran S.

Anti-atherogenic effects of supplementation with vitamin B6 (Pyridoxine) in albino rats

November 2011

Elevation of serum lipids have been implicated to predispose to cardiovascular disorders which includes hypertension, stroke, atherosclerosis etc. Various studies have reported links between supplementation with vitamin B complex and reduction in oxidative stress and inflammatory reactions, two events associated with cardiovascular disorders. Data on possible direct regulation on lipid profile by vitamin B6 is very...

Author(s): Adekunle Adeniran S. and Adedeji Adebayo L.

Screening of antioxidant activity, total phenolics and gas chromatograph and mass spectrometer (GC-MS) study of delonix regia

October 2011

The present study was carried out for identification of the phytochemicals present in the Delonix regia leaves and also evaluates the total phenols, total flavonoids and antioxidant activity of the leaf extract. Total phenols were carried out by Folin Ciocalteu method and the phenolic content was 16.00 mg/100 g of gallic acid equivalent (GE). Antioxidant activity was evaluated by 2,2-Diphenyl-1-Picrylhydrazyl...

Author(s): P. Maria jancy Rani, P. S. M. Kannan and S. Kumaravel

Antioxidant activity of methanolic extract of Pongamia pinnata on lead acetate induced hepatic damage in rats

October 2011

The antioxidant effect of methanolic extract of Pongamia pinnata was evaluated against lead acetate induced hepatic damage in male albino rats. Methanolic extract from the flowers of P. pinnata at a dose level of 150 mg/kg b.wt/day was administered orally daily once for 90 days. The substantially decreased enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione...

Author(s): R. Anuradha and Palaniyandi Krishnamoorthy

Oxidative stress biomarkers in young male rats fed with stevioside

October 2011

Stevioside is a natural non-caloric sweetener refined from Stevia rebaudiana Bertoni leaves. The introduction of stevioside as a sugar substitute in the diets of diabetics and others on carbohydrate-controlled diets has been suggested, but safety issues have prevented implementation. The aim of this study was to examine antioxidant status changes in the sera, livers and kidneys of young male rats fed with low...

Author(s): Hala A. Awney

Anti-malarial activity of cocoa powder in mice

October 2011

At present, malaria is one of the most important parasitic diseases in the world killing more than one million people annually. It is an important public health problem because many of the drugs that are being prescribed for the treatment of malaria have become ineffective to the disease. This study was therefore carried out to determine the anti-malaria activity of cocoa powder through the use of mouse model. Natural...

Author(s): Jayeola, C. O., Oluwadun, A., Olubamiwa, O., Effedua, H. I. and Kale, O. E

Chelating ability of sulbactomax drug in arsenic intoxication

September 2011

The aim of this study was to determine the chelating ability of Sulbactomax drug in arsenic pre-exposed rats. 24 rats were divided into I to III groups. Group I was control while Groups II to III were arsenic exposed and arsenic plus Sulbactomax treated group. Arsenic toxicity was induced via intraperitoneally administration of arsenic trioxide (As2O3) 10 mg/kg body weight/day for three weeks. Toxicity...

Author(s): V. K. Dwivedi, A. Arya, H. Gupta, A. Bhatnagar, P. Kumar and M. Chaudhary

Reduction of platelet and lymphocyte counts and elevation of neutrophil counts in rats treated with aqueous leaf extract of Ocimum gratissimum

September 2011

Ocimum gratissimum (Linn.) has been widely used for food and medicinal purposes.  The effect of aqueous leaf extract of O. gratissimum on haematological parameters of albino Wistar rats was studied.  Acute toxicity study showed a median lethal dose (LD50) value of 2121.32 mg/kg body weight for intraperitoneal (i. p) route in mice. Twenty rats’ weights ranging between 85 to 115 g...

Author(s): Okon U. A., Ita S. O., Ekpenyong C. E., Davies, K. G. and Inyang, O. I.

Influence of the bioinsecticides, NeemAzal, on main body metabolites of the 3rd larval instar of the house fly Musca domestica (Diptera: Muscidae)

September 2011

The present study was designed and conducted to determine the effects of Neemazal on the general body metabolism of the house fly Musca domestica. The second instar larvae of the house fly M. domestica (L.) were reared on artificial diet treated with the botanical extract, NeemAzal. Five concentration levels of this compound (1000, 500, 250, 125 and 62.5 ppm) were used. The main body metabolites,...

Author(s): Mohammad A. Kassem, Tarek A. Mohammad and Ahmad S. Bream

Changes in liver and serum transaminases and alkaline phosphatase enzyme activities in Plasmodium berghei infected mice treated with aqueous extract of Aframomum sceptrum

September 2011

One of the effects of Plasmodium infection which causes malaria is the invasion of the hepatocyte which affects liver and blood transaminases activities. This study was design to examine the hepato-protective effect of Aframomum sceptrum in mice infected withPlasmodium berghei. Thirty-six abino male mice infected (test) and non infected (control) of 8 weeks old were used for this research. The...

Author(s): George, B. O., Osioma, E., Okpoghono, J. and Aina, O. O.

Effect of highly active anti-retroviral therapy (HAART) on lipid profile in a human immunodeficiency virus (HIV) infected Nigerian population

September 2011

Nigeria remains the country with the third highest number of human immunodeficiency virus (HIV) infected individuals with over 600,000 HIV-infected subjects requiring antiretroviral therapy (ART). Since there is little or no data on the effect of highly active antiretroviral therapy (HAART) on the lipid profile of HIV-infected subjects in Nigeria, this study was aimed at evaluating the dyslipidaemia associated with...

Author(s): Francis M. Awah, and Onyinye Agughasi

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